Society of Friends of Science in Wilno (Polish: Towarzystwo Przyjaciół Nauk w Wilnie) was a Polish scientific society which functioned in Wilno (now Vilnius, Lithuania) from 1906 to 1939. The Society was involved with the reopening of the Stefan Batory University in Wilno. One of its presidents has been Marian Zdziechowski, a popular figure in the pre-WWII Wilno.
The Society was destroyed during World War II by the Lithuanian, Soviet and Nazi occupying authorities.